TÀI LIỆU THAM KHẢO CHO BÁC SỸ CHUYÊN KHOA - NO.2

Effect of the administration of antioxidant complex in patients affected by Idiopathic Astheno Teratozoospermia

Ballescá, José Luis; Oliva, Rafael; Espinosa, Nadia; Corral, Juan Manuel. Rev Int Androl.2012; 10 :51-6 - vol.10 núm 02.

Introduction:

The male factor is noted in almost 50% of couples who see a consultant because of reproductive problems and it can be a consequence of reduced sperm motility (Oligozoospermia) or a deterioration in its quality because of defects in its motility or in its morphology (Teratozoospermia). Various studies exist that link these defects in sperm quality with changes in DNA sperm fragmentation and present the possible beneficial effect of antioxidant treatments, even though great differences exist in the results obtained.

Objectives:

In order to shed light on the possible beneficial effect of the empirical administration of antioxidants, in the current piece of work we tackle the study of the effect of the administration of antioxidant complex (Androferti®/OXIMUM®, Laboratories Q Pharma), in patients affected by Idiopathic Astheno Teratozoospermia.

Patients and methods:

In order to do this, a total of 69 men were administered the antioxidant treatment, at a dose of 1.5g per day over three months. On conclusion of the treatment, they detected a significant improvement in motility (the global motility a+b went from 22.04 to 28.95%; p = 0.001) and morphology (the normal forms went from 9.86 to 14.78%; p<0.001).

Discussion:

Numerous publications refer to the beneficial effects of administering antioxidant substances on the DNA sperm fragmentation which could be interpreted as an improvement in seminal and embryonic quality, in the event of pregnancy. Our study has found similar findings, showing an improvement in the majority of the seminal parameters as a consequence of the administration of L-Carnitine associated with other antioxidant action substances, treatment which seems to be particularly efficient in younger patients.

Conclusions:

Our results confirm the beneficial effect of the administration of antioxidant complex in patients affected by Idiopathic Astheno Teratozoospermia, improving the semen quality and consequently favouring the desired pregnancy.

OXIMUM - DATA ON FILE.